Bio-X: Multidisciplinary Research and Education at Stanford

John Hennessey, Ph.D.
President, Stanford University

When multiple disciplines come together and different perspectives are shared, there's no limit to the collaboration, creativity, and innovation that can occur. Entrepreneurship and entrepreneurial thinking thrives. In the essay that follows, John Hennessey describes the success at Stanford University in creating a multidisciplinary approach to research and teaching in the biosciences.

In the late 1990s, two Stanford professors, one a physicist and the other a biologist, began collaborating on manipulating and measuring forces associated with motor proteins. They so enjoyed working together that they convened a broader faculty group to discuss how the university could foster more collaborative research and teaching in the biosciences. A principal outcome of this initial meeting, and many subsequent ones, was a university-wide research and teaching program, called Bio-X, which is dedicated to bringing basic science to bear on critical biomedical and other human needs through the fostering of multidisciplinary efforts.

The interdisciplinary research being carried out at Bio-X reflects the reality that significant biomedical problems cannot be solved without the coordinated application of tools and knowledge from many disciplines. An example is tissue engineering, which brings together cell biology, molecular biology, materials science, mechanical engineering, chemical engineering, electrical engineering, and clinical medicine.

At the core of Bio-X are thirty-eight faculty researchers whose offices and labs are collocated in the Clark Center, a new, state-of-the-art building that has become a community center for science. These faculty come from more than twenty different departments, including genetics, computer science, physiology, neurology, mechanical engineering, statistics, and medicine. Connecting with this faculty core are various networks of other Stanford faculty—Bio-X currently has more than three hundred faculty affiliates in fifty departments. It is this broad universe of faculty and the more than 1,500 affiliated students and postdoctoral scholars who make up the whole of Bio-X. Frequent scientific events in the Clark Center, shared core facilities such as supercomputers and imaging instruments—and first-rate coffee—draw in collaborating researchers from all over campus and around the world.

Bio-X was from the beginning a network—a network of potential entrepreneurial collaborations. These Bio-X networks arise and expand from the continuing departmental affiliations of the Clark Center residents, from lectures designed for scientist and nonscientist alike (including the popular "Talks in English" series), and from an innovative program that provides seed funds for students and faculty engaged in interdisciplinary research (the Interdisciplinary Initiatives Program), which operates not unlike seed or angel funding in the entrepreneurial business world. These forty grants, with another twenty about to be awarded, have fostered work from ethics to elephant communication, surgical robotics, vaccine development, coral reef ecology, and neural prosthetics. Bio-X also fosters collaboration through grants of graduate and postdoctoral fellowships for interdisciplinary research and education; these fellowships attract the best young scholars in the world to Bio-X. One of the added benefits of the Bio-X seed grants and fellowships is that faculty who serve on the selection committees find themselves learning from one another about the cutting-edge bioscience issues touching their various disciplines.

Building Bridges

In addition to its role as a central resource for Stanford faculty and students, Bio-X is playing a key role in building bridges between the university and a wider community of scientists, public and private industry representatives, and policymakers. For instance, every year Bio-X hosts a major symposium on contemporary bioscience topics of widespread interest. Last year's topic, "Watching Life" (about advances in imaging), drew hundreds of attendees from Stanford, other universities, and biotechnology corporations, and this year's symposium on "Regenerating Life" is expected to do the same. In addition, the Bio-X Advisory Council, whose members include executives, investors, and scientists associated with medical, biotechnology, and pharmaceutical companies, carries on a periodic dialogue with Bio-X faculty. This dialogue helps the university know what is happening in industry and vice versa, leading to increased opportunities for collaboration, technology transfer, and donor interest. In this regard, Bio-X is able to take advantage of Stanford's history of good working relationships with industry in other areas of technology.

What We've Learned

We have learned much about interdisciplinary bioscience research and education since Bio-X began. First and foremost, the success of Bio-X is attributable to its origins as a faculty-driven effort. A promising interdisciplinary effort is not likely to flourish if it's imposed on a team of researchers. For example, experts from different fields need to take the time to learn how to bridge their field-specific "cultural" and linguistic styles, and this effort requires a personal commitment and willingness that would be absent if imposed top-down. The university's role is to build upon the faculty's enthusiasm for a new interdisciplinary scientific opportunity by providing adequate resources and support. We were fortunate at Stanford to be able to construct the Clark Center around the needs of Bio-X. We are also fortunate to have all of our schools, including the Schools of Humanities and Sciences, Medicine, and Engineering, collocated on one contiguous campus and to have a rich history of faculty interaction across that campus.

Another lesson came from our early decision not to predefine the research themes within the Clark Center too strictly. Our goal was to achieve critical mass within the Clark Center in certain areas while encompassing the broadest possible spectrum of biological research areas. A related early decision was to not allocate all the space in the Clark Center on day one, but to preserve space for future "hot-shot" hires and to allocate some space as hotel space, which could be allocated on a time-limited basis to promising new activities. Faculty recruitment has in fact gone exceedingly well, even in competition with other fine universities. Often the new recruits have commented that it was the excitement of Bio-X and the Clark Center that drew them here.

Benefits Across Disciplines

Since the establishment of Bio-X, Stanford faculty have initiated similar interdisciplinary programs in the international and environmental areas. Increasingly we believe that in research, finding solutions to complex and difficult problems—from overcoming disease to finding alternative eco-friendly energy sources to developing policies that increase prosperity and reduce societal conflict—requires collaboration among experts from multiple disciplines. These kinds of problems will not succumb to the efforts of a single researcher with one disciplinary skill; they are too large and too complex. In addition, many of the most important opportunities for advancement lie not in the center of a discipline but at the boundaries and interstitial spaces between disciplines. Universities must become more adept at exploiting such opportunities.

In education, too, Stanford increasingly sees the need for students, especially at the graduate level, where training tends to be relatively focused and narrow, to have broader skills and exposure. These students reap longstanding benefits from an introduction to, for example, the principles of modern businesses or the legal concepts surrounding the ownership of intellectual property or the uses and potential of high technology. Our graduates, in their various roles in society, are increasingly being asked to work in teams that combine different skills sets. We believe that having a better understanding of related disciplines and some common vocabulary will make our graduates, whether scientists, humanists, engineers, lawyers, doctors, educators, or corporate executives, more effective as team members and team leaders.

Stanford remains solidly committed to deep disciplinary expertise. It also is committed to multidisciplinary collaboration and to bringing teams together to help solve seemingly intractable problems. Thanks to the foresight and energy of Stanford faculty who simply wanted to work together on a problem of common interest, Bio-X came into being, and thanks to its successes, Stanford has a better understanding of how to mount multidisciplinary programs in other areas. While universities alone cannot provide complete solutions to society's most difficult problems, we can play a large and important role. At Stanford, we are proud to be fulfilling our historic commitment to—in the words of Jane and Leland Stanford—"promote the public welfare by exercising an influence on behalf of humanity and civilization."

TB cover 2009This essay is an excerpt from the Kauffman Thoughtbook 2007. To view a table of contents for the 2009 edition, or to order a printed copy of the publication, please visit our 2009 Thoughtbook page  

Initiatives